First synthesis of (±)-myristicyclin A

Shinichiro Kubo, Naoki Mori, Hidenori Watanabe, Hirosato Takikawa

Research output: Contribution to journalArticle

Abstract

The first synthesis of myristicyclin A, which was isolated from the Papua New Guinean plant Horsfieldia spicata, is described. The synthesis features acid-mediated hydroarylation reaction to form a dihydrocoumarin moiety, construction of the 2,8-dioxabicyclo[3.3.1]nonane skeleton under acidic conditions, and regioselective Friedel-Crafts acylation at a later stage.

Original languageEnglish
Pages (from-to)1867-1870
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume82
Issue number11
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Keywords

  • Antimalarial
  • Friedel-Crafts acylation
  • Myristicyclin A
  • Synthesis

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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