First synthesis of BU-4664L

Yusuke Takahashi, Takafumi Hirokawa, Mai Watanabe, Satomi Fujita, Yusuke Ogura, Masaru Enomoto, Shigefumi Kuwahara

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)


    The first synthesis of BU-4664L, an actinomycte-produced N-farnesylated dibenzodiazepinone with important biological activities, has been achieved in 18% overall yield from a known benzoic acid derivative by a nine-step sequence that involves an intramolecular Buchwald-Hartwig coupling of a sterically demanding bromo amine intermediate to install the unique tricyclic ring system.

    Original languageEnglish
    Pages (from-to)5670-5672
    Number of pages3
    JournalTetrahedron Letters
    Issue number41
    Publication statusPublished - 2015 Oct 7


    • Alkaloid
    • Antitumor
    • BU-4664L
    • Buchwald-Hartwig reaction
    • Diazepinomicin

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry


    Dive into the research topics of 'First synthesis of BU-4664L'. Together they form a unique fingerprint.

    Cite this