Abstract
A practical two-step synthetic process for 1-deoxy sugars has been established. The process consists of the direct introduction of a dimethyldithiocarbamate group into the anomeric center of unprotected sugars and subsequent hydrogenation in the AIBN-H3PO2-NaHCO3 system. No protecting groups are needed to synthesize 1-deoxy monosaccharides and 1-deoxy disaccharides.
Original language | English |
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Pages (from-to) | 3428-3431 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 59 |
Issue number | 37 |
DOIs | |
Publication status | Published - 2018 Sep 12 |
Keywords
- 1-Deoxy sugar
- Direct anomeric activation
- Glycosyl dithiocarbamate
- Protection-free synthesis
- Radical desulfurization
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry