First fluorescent photoinduced electron transfer (PET) reagent for hydroperoxides

Maki Onoda, Seiichi Uchiyama, Atsushi Endo, Hidetoshi Tokuyama, Tomofumi Santa, Kazuhiro Imai

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

(Matrix presented) A novel fluorescent reagent for hydroperoxides, 4-(2-diphenylphosphinoethylamino)-7-nitro-2,1,3-benzoxadiazole (1), was developed on the basis of the method for designing photoinduced electron transfer (PET) reagents having a benzofurazan skeleton. Compound 1 was quantitatively reacted with hydroperoxides to give its fluorescent derivative, 2. In acetonitrile, the Φ value (0.44) of 2 was 31 times greater than that of 1. The long excitation (458 nm) and emission (520 nm) wavelengths of 2 are suitable for the determination of hydroperoxides, especially in biosamples.

Original languageEnglish
Pages (from-to)1459-1461
Number of pages3
JournalOrganic letters
Volume5
Issue number9
DOIs
Publication statusPublished - 2003 May 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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