First enantioselective synthesis of salinipostin A, a marine cyclic enol-phosphotriester isolated from Salinispora sp

Hironori Okamura, Takanobu Fujioka, N. Mori, T. Taniguchi, K. Monde, Hidenori Watanabe, Hirosato Takikawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Salinipostins are cyclic enol-phosphotriesters isolated from a marine-derived Salinispora sp. as antimalarial compounds. Herein, the first enantioselective synthesis of salinipostin A was achieved. Organocatalyst-mediated asymmetric cyclopropanation and regioselective cyclopropane ring opening were the key steps.

Original languageEnglish
Article number150917
JournalTetrahedron Letters
Volume60
Issue number32
DOIs
Publication statusPublished - 2019 Aug 8
Externally publishedYes

Keywords

  • Asymmetric cyclopropanation
  • Hayashi-Jørgensen catalyst
  • Marine natural product
  • Salinipostins

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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