First asymmetric photochemistry with nucleosides and DNA: Enantiodifferentiating Z-E photoisomerization of cyclooctene

Takehiko Wada, Norimitsu Sugahara, Mahito Kawano, Yoshihisa Inoue

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Thymidine and uridine, as well as calf thymus DNA (ctDNA), have been shown for the first time to function as chiral photosensitizers in aqueous solution, to effect the enantiodifferentiating photoisomerization of (Z)-cyclooctene, giving the chiral (E)-isomer in enantiomeric excesses of up to 15%.

Original languageEnglish
Pages (from-to)1174-1175
Number of pages2
JournalChemistry Letters
Issue number10
DOIs
Publication statusPublished - 2000 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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