First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner

K. Ishii, Y. Kikuchi, S. Matsuyama, Y. Kanai, K. Kotani, T. Ito, H. Yamazaki, Y. Funaki, R. Iwata, M. Itoh, K. Yanai, J. Hatazawa, N. Itoh, N. Tanizaki, D. Amano, M. Yamada, T. Yamaguchi

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

An animal PET scanner using CdTe detectors was developed for the purpose of biomedical study using mice and rats. A spatial resolution of 0.8 mm FWHM within the central 20 mm-diameter of the field of view (FOV) was obtained by small CdTe elements of 1.1 mm×5.0 mm×1.0 mm. This spatial resolution is the first achievement of a practical semiconductor animal PET scanner. The determination of the depth of the γ interaction in the detector was carried out by the use of two detector layers. The FOV is 64 mm in diameter and 26 mm in axis. Fine [18F]FDG images of the heads of a mouse and a rat, where the cerebral cortex, the gray matter and the corpus striatum could be respectively distinguished, were successfully obtained. This work inspires the dawn of the high resolution semiconductor PET scanner age as the next generation.

Original languageEnglish
Pages (from-to)435-440
Number of pages6
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume576
Issue number2-3
DOIs
Publication statusPublished - 2007 Jun 21

Keywords

  • Animal PET
  • CdTe
  • High resolution
  • Positron emission tomograph
  • Semiconductor detector

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Instrumentation

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