Fins and limbs: Emergence of morphological differences

Tohru Yano, Haruka Matsubara, Shiro Egawa, Koun Onodera, Koji Tamura

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Paired appendages (fins and limbs) are regarded as distinct morphologies by classification of skeletal patterns. On the basis of sequential orientation and articulation of tetrapod limb bones, we can understand that stylopodial/zeugopodial skeletal elements are present in an extinct and extant basal sarcopterygian (coelacanth and lungfish) fin and that only nonhomologous radial bones exist in a zebrafish fin. From these phylogenetic views, morphological differences between fins and limbs and paleontological discoveries of limb-like fins of basal sarcopterygians emphasize both the homologous skeletal elements and tetrapodomorph evolution. During embryogenesis, on the other hand, initial fin development requires apical ectodermal ridge (AER) signals as does tetrapod limb development, and then the AER itself starts to transform into a fin-specific structure, the apical fold (AF). HoxD genes are involved in fish fin development as in tetrapod limb development, but the resultant skeletal patterns of fins are very different from those of limbs as a result of differences in regulation of genes such as HoxD. From these developmental aspects, we can understand that both fins and limbs develop by common mechanisms, including fibroblast growth factors (FGFs) from the AER and Hox genes, and that alteration of basic mechanisms by heterochronic/heterometric change in expression of AER/AF signals and Hox gives rise to morphological differences among paired appendages. In this chapter, we describe homology and difference in several research fields (genome commonality/difference, developmental commonality/difference, and anatomical or paleontological correspondence/difference) and especially explain a scenario of fin-to-limb evolution.

    Original languageEnglish
    Title of host publicationNew Principles in Developmental Processes
    PublisherSpringer Japan
    Pages291-302
    Number of pages12
    Volume9784431546344
    ISBN (Electronic)9784431546344
    ISBN (Print)4431546332, 9784431546337
    DOIs
    Publication statusPublished - 2014 Nov 1

    Keywords

    • Endoskeleton
    • Exoskeleton
    • Fin
    • Limb

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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