The distribution and fine structure of these nerve fibres was examined by immunoelectron microscopy. CGRP-immunoreactive fibres were seen in the nerve bundles, blood vessels and periosteum around the condyle as well as in the disc. These nerve fibres were unmyelinated and had diameters varying from 200 to 600 nm. They were completely or partially enclosed by Schwann cell cytoplasm and did not form synaptic contact with any cells. CGRP-immunoreactive nerve fibres may be of sensory nature and this peptide could be involved in pain transmission and neurogenic inflammation.
- calcitonin gene-related peptide
- temporomandibular joint
ASJC Scopus subject areas
- Cell Biology