Filament perforation subarachnoid hemorrhage: Mouse model

Hideyuki Kamii, Teiji Tominaga

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The filament perforation subarachnoid hemorrhage (SAH) mouse model mimics a clinical situation with aneurysmal SAH in humans. In this model, subarachnoid clot induces vasospasm, which has a peak at 3 days after SAH. Moreover, a sudden increase in intracranial pressure immediately after the arterial perforation induces cortical neuronal damage similar to aneurysmal SAH in humans. Therefore, this model is suitable for researches on the various pathophysiologies of SAH. Although uncontrollable volume of SAH basically causes high mortality rate in this model, our techniques perforating the anterior cerebral artery can lead to less mortality and relatively reproducible state after SAH. The complications and limitations in this model are also discussed.

Original languageEnglish
Title of host publicationAnimal Models of Acute Neurological Injuries
PublisherHumana Press
Pages279-286
Number of pages8
ISBN (Print)9781603271844
DOIs
Publication statusPublished - 2009

Keywords

  • Filament
  • Model
  • Mouse
  • Perforation
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)

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