Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population

Wataru Satake, Ikuko Mizuta, Satoko Suzuki, Yuko Nakabayashi, Chiyomi Ito, Masahiko Watanabe, Atsushi Takeda, Kazuko Hasegawa, Saburo Sakoda, Mitsutoshi Yamamoto, Nobutaka Hattori, Miho Murata, Tatsushi Toda

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31 Citations (Scopus)

Abstract

A genetic association between the fibroblast growth factor 20 (FGF20) gene and Parkinson's disease has been found by the pedigree disequilibrium test. This association, however, was not replicated by a case-control association study. In order to clarify the association between the FGF20 gene and Parkinson's disease, we attempted to replicate this association by a case-control association study using a large number of Japanese samples (1388 patients and 1891 controls). rs1721100 exhibited a significant difference in allele C versus G (P=0.0089), and in genotype CC+CG versus GG (P=0.0053). Haplotype association analysis showed that haplotype 2 was the protective haplotype for Parkinson's disease (permutation-P=0.0075). These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population.

Original languageEnglish
Pages (from-to)937-940
Number of pages4
JournalNeuroReport
Volume18
Issue number9
DOIs
Publication statusPublished - 2007 Jun

Keywords

  • Association
  • Case-control study
  • Fibroblast growth factor 20 (FGF20)
  • Parkinson's disease
  • Single nucleotide polymorphism
  • Susceptibility gene

ASJC Scopus subject areas

  • Neuroscience(all)

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    Satake, W., Mizuta, I., Suzuki, S., Nakabayashi, Y., Ito, C., Watanabe, M., Takeda, A., Hasegawa, K., Sakoda, S., Yamamoto, M., Hattori, N., Murata, M., & Toda, T. (2007). Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population. NeuroReport, 18(9), 937-940. https://doi.org/10.1097/WNR.0b013e328133265b