Fibroblast growth factor-2 stimulates hyaluronan production by human dental pulp cells

Yoshio Shimabukuro; Maki Ueda; Tomoo Ichikawa; Yoshimitsu Terashi; Satoru Yamada; Yutaka Kusumoto; Masahide Takedachi; Mami Terakura; Akira Kohya; Tomoko Hashikawa; Shinya Murakami

doi:10.1097/01.don.0000158242.44155.49

Fibroblast growth factor-2 stimulates hyaluronan production by human dental pulp cells

Yoshio Shimabukuro, Maki Ueda, Tomoo Ichikawa, Yoshimitsu Terashi, Satoru Yamada, Yutaka Kusumoto, Masahide Takedachi, Mami Terakura, Akira Kohya, Tomoko Hashikawa, Shinya Murakami

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Hyaluronan (HA), is a high molecular mass extracellular matrix constituting connective tissue and plays a critical role in not only homeostasis but also inflammatory and wound-healing responses. In this study, we investigated the effect of fibroblast growth factor (FGF)-2 on the production of HA by human dental pulp cells (HDPC). An inhibition binding-protein assay showed that FGF-2 increased HA production by HDPC. In addition, expression of mRNA of hyaluronan synthase (HAS) 1 and HAS 2, both of which are related to the production of high molecular mass of HA, but not HAS 3, was enhanced in FGF-2-stimulated HDPC. These results provide new evidence for the involvement of FGF-2 in the regulation of HA production by HDPC possibly through HAS 1 and HAS 2.

Original language	English
Pages (from-to)	805-808
Number of pages	4
Journal	Journal of endodontics
Volume	31
Issue number	11
DOIs	https://doi.org/10.1097/01.don.0000158242.44155.49
Publication status	Published - 2005 Nov
Externally published	Yes

Keywords

Dental pulp cell
FGF-2
Hyaluronan
Hyaluronan synthase

ASJC Scopus subject areas

Dentistry(all)

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Fibroblast growth factor-2 stimulates hyaluronan production by human dental pulp cells. / Shimabukuro, Yoshio; Ueda, Maki; Ichikawa, Tomoo; Terashi, Yoshimitsu; Yamada, Satoru; Kusumoto, Yutaka; Takedachi, Masahide; Terakura, Mami; Kohya, Akira; Hashikawa, Tomoko; Murakami, Shinya.

In: Journal of endodontics, Vol. 31, No. 11, 11.2005, p. 805-808.

Research output: Contribution to journal › Article › peer-review

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abstract = "Hyaluronan (HA), is a high molecular mass extracellular matrix constituting connective tissue and plays a critical role in not only homeostasis but also inflammatory and wound-healing responses. In this study, we investigated the effect of fibroblast growth factor (FGF)-2 on the production of HA by human dental pulp cells (HDPC). An inhibition binding-protein assay showed that FGF-2 increased HA production by HDPC. In addition, expression of mRNA of hyaluronan synthase (HAS) 1 and HAS 2, both of which are related to the production of high molecular mass of HA, but not HAS 3, was enhanced in FGF-2-stimulated HDPC. These results provide new evidence for the involvement of FGF-2 in the regulation of HA production by HDPC possibly through HAS 1 and HAS 2.",

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author = "Yoshio Shimabukuro and Maki Ueda and Tomoo Ichikawa and Yoshimitsu Terashi and Satoru Yamada and Yutaka Kusumoto and Masahide Takedachi and Mami Terakura and Akira Kohya and Tomoko Hashikawa and Shinya Murakami",

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AU - Shimabukuro, Yoshio

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AU - Ichikawa, Tomoo

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AU - Yamada, Satoru

AU - Kusumoto, Yutaka

AU - Takedachi, Masahide

AU - Terakura, Mami

AU - Kohya, Akira

AU - Hashikawa, Tomoko

AU - Murakami, Shinya

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AB - Hyaluronan (HA), is a high molecular mass extracellular matrix constituting connective tissue and plays a critical role in not only homeostasis but also inflammatory and wound-healing responses. In this study, we investigated the effect of fibroblast growth factor (FGF)-2 on the production of HA by human dental pulp cells (HDPC). An inhibition binding-protein assay showed that FGF-2 increased HA production by HDPC. In addition, expression of mRNA of hyaluronan synthase (HAS) 1 and HAS 2, both of which are related to the production of high molecular mass of HA, but not HAS 3, was enhanced in FGF-2-stimulated HDPC. These results provide new evidence for the involvement of FGF-2 in the regulation of HA production by HDPC possibly through HAS 1 and HAS 2.

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