Fibroblast growth factor-2 stimulates hyaluronan production by human dental pulp cells

Yoshio Shimabukuro, Maki Ueda, Tomoo Ichikawa, Yoshimitsu Terashi, Satoru Yamada, Yutaka Kusumoto, Masahide Takedachi, Mami Terakura, Akira Kohya, Tomoko Hashikawa, Shinya Murakami

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Hyaluronan (HA), is a high molecular mass extracellular matrix constituting connective tissue and plays a critical role in not only homeostasis but also inflammatory and wound-healing responses. In this study, we investigated the effect of fibroblast growth factor (FGF)-2 on the production of HA by human dental pulp cells (HDPC). An inhibition binding-protein assay showed that FGF-2 increased HA production by HDPC. In addition, expression of mRNA of hyaluronan synthase (HAS) 1 and HAS 2, both of which are related to the production of high molecular mass of HA, but not HAS 3, was enhanced in FGF-2-stimulated HDPC. These results provide new evidence for the involvement of FGF-2 in the regulation of HA production by HDPC possibly through HAS 1 and HAS 2.

Original languageEnglish
Pages (from-to)805-808
Number of pages4
JournalJournal of endodontics
Volume31
Issue number11
DOIs
Publication statusPublished - 2005 Nov
Externally publishedYes

Keywords

  • Dental pulp cell
  • FGF-2
  • Hyaluronan
  • Hyaluronan synthase

ASJC Scopus subject areas

  • Dentistry(all)

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