Fibroblast growth factor-2 inhibits CD40-mediated periodontal inflammation

Chiharu Fujihara, Yu Kanai, Risa Masumoto, Jirouta Kitagaki, Masahiro Matsumoto, Satoru Yamada, Tetsuhiro Kajikawa, Shinya Murakami

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Fibroblast growth factor-2 (FGF-2) stimulates periodontal regeneration by a broad spectrum of effects on periodontal ligament (PDL) cells, such as proliferation, migration, and production of extracellular matrix. A critical factor in the success of periodontal regeneration is the rapid resolution of inflammatory responses in the tissue. We explored an anti-inflammatory effect of FGF-2 during periodontal regeneration and healing. We found that FGF-2 on mouse periodontal ligament cells (MPDL22) markedly downregulated CD40 expression, a key player of inflammation. In addition, FGF-2 inhibited CD40 signaling by the non-canonical nuclear factor-kappa B2 (NFκB2) pathway, resulting in decreased production of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), which have the potential to recruit immune cells to inflamed sites. Furthermore, in vivo treatment of FGF-2 enhanced healing of skin wounds by counteracting the CD40-mediated inflammation. These results reveal that FGF-2 has an important function as a negative regulator of inflammation during periodontal regeneration and healing.

Original languageEnglish
Pages (from-to)7149-7160
Number of pages12
JournalJournal of Cellular Physiology
Volume234
Issue number5
DOIs
Publication statusPublished - 2019 May

Keywords

  • CD40
  • anti-inflammation
  • fibroblast growth factor-2 (FGF-2)
  • periodontal ligament (PDL) cells
  • wound healing

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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