Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment

Masahiro Yamanari; Satoru Tsuda; Taiki Kokubun; Yukihiro Shiga; Kazuko Omodaka; Yu Yokoyama; Noriko Himori; Morin Ryu; Shiho Kunimatsu-Sanuki; Hidetoshi Takahashi; Kazuichi Maruyama; Hiroshi Kunikata; Toru Nakazawa

doi:10.1364/BOE.6.000369

Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment

Masahiro Yamanari, Satoru Tsuda, Taiki Kokubun, Yukihiro Shiga, Kazuko Omodaka, Yu Yokoyama, Noriko Himori, Morin Ryu, Shiho Kunimatsu-Sanuki, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We demonstrate a prototype system of polarization-sensitive optical coherence tomography (PS-OCT) designed for clinical studies of the anterior eye segment imaging. The system can measure Jones matrices of the sample with depth-multiplexing of two orthogonal incident polarizations and polarization-sensitive detection. An optical clock is generated using a quadrature modulator and a logical circuit to double the clock frequency. Systematic artifacts in measured Jones matrices are theoretically analyzed and numerically compensated using signals at the surface of the sample. Local retardation images of filtering blebs after trabeculectomy show improved visualization of subconjunctival tissue, sclera, and scar tissue of the bleb wall in the anterior eye segment.

Original language	English
Pages (from-to)	369-389
Number of pages	21
Journal	Biomedical Optics Express
Volume	6
Issue number	2
DOIs	https://doi.org/10.1364/BOE.6.000369
Publication status	Published - 2015

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

Access to Document

10.1364/BOE.6.000369

Fingerprint Dive into the research topics of 'Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment'. Together they form a unique fingerprint.

Cite this

Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment. / Yamanari, Masahiro; Tsuda, Satoru ; Kokubun, Taiki; Shiga, Yukihiro; Omodaka, Kazuko ; Yokoyama, Yu ; Himori, Noriko; Ryu, Morin; Kunimatsu-Sanuki, Shiho; Takahashi, Hidetoshi; Maruyama, Kazuichi; Kunikata, Hiroshi ; Nakazawa, Toru.

In: Biomedical Optics Express, Vol. 6, No. 2, 2015, p. 369-389.

Research output: Contribution to journal › Article › peer-review

Yamanari, Masahiro ; Tsuda, Satoru ; Kokubun, Taiki ; Shiga, Yukihiro ; Omodaka, Kazuko ; Yokoyama, Yu ; Himori, Noriko ; Ryu, Morin ; Kunimatsu-Sanuki, Shiho ; Takahashi, Hidetoshi ; Maruyama, Kazuichi ; Kunikata, Hiroshi ; Nakazawa, Toru. / Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment. In: Biomedical Optics Express. 2015 ; Vol. 6, No. 2. pp. 369-389.

@article{bf39d9191b5343ab9093cdd7a257323d,

title = "Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment",

abstract = "We demonstrate a prototype system of polarization-sensitive optical coherence tomography (PS-OCT) designed for clinical studies of the anterior eye segment imaging. The system can measure Jones matrices of the sample with depth-multiplexing of two orthogonal incident polarizations and polarization-sensitive detection. An optical clock is generated using a quadrature modulator and a logical circuit to double the clock frequency. Systematic artifacts in measured Jones matrices are theoretically analyzed and numerically compensated using signals at the surface of the sample. Local retardation images of filtering blebs after trabeculectomy show improved visualization of subconjunctival tissue, sclera, and scar tissue of the bleb wall in the anterior eye segment.",

author = "Masahiro Yamanari and Satoru Tsuda and Taiki Kokubun and Yukihiro Shiga and Kazuko Omodaka and Yu Yokoyama and Noriko Himori and Morin Ryu and Shiho Kunimatsu-Sanuki and Hidetoshi Takahashi and Kazuichi Maruyama and Hiroshi Kunikata and Toru Nakazawa",

year = "2015",

doi = "10.1364/BOE.6.000369",

language = "English",

volume = "6",

pages = "369--389",

journal = "Biomedical Optics Express",

issn = "2156-7085",

publisher = "The Optical Society",

number = "2",

}

TY - JOUR

T1 - Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment

AU - Yamanari, Masahiro

AU - Tsuda, Satoru

AU - Kokubun, Taiki

AU - Shiga, Yukihiro

AU - Omodaka, Kazuko

AU - Yokoyama, Yu

AU - Himori, Noriko

AU - Ryu, Morin

AU - Kunimatsu-Sanuki, Shiho

AU - Takahashi, Hidetoshi

AU - Maruyama, Kazuichi

AU - Kunikata, Hiroshi

AU - Nakazawa, Toru

PY - 2015

Y1 - 2015

N2 - We demonstrate a prototype system of polarization-sensitive optical coherence tomography (PS-OCT) designed for clinical studies of the anterior eye segment imaging. The system can measure Jones matrices of the sample with depth-multiplexing of two orthogonal incident polarizations and polarization-sensitive detection. An optical clock is generated using a quadrature modulator and a logical circuit to double the clock frequency. Systematic artifacts in measured Jones matrices are theoretically analyzed and numerically compensated using signals at the surface of the sample. Local retardation images of filtering blebs after trabeculectomy show improved visualization of subconjunctival tissue, sclera, and scar tissue of the bleb wall in the anterior eye segment.

AB - We demonstrate a prototype system of polarization-sensitive optical coherence tomography (PS-OCT) designed for clinical studies of the anterior eye segment imaging. The system can measure Jones matrices of the sample with depth-multiplexing of two orthogonal incident polarizations and polarization-sensitive detection. An optical clock is generated using a quadrature modulator and a logical circuit to double the clock frequency. Systematic artifacts in measured Jones matrices are theoretically analyzed and numerically compensated using signals at the surface of the sample. Local retardation images of filtering blebs after trabeculectomy show improved visualization of subconjunctival tissue, sclera, and scar tissue of the bleb wall in the anterior eye segment.

UR - http://www.scopus.com/inward/record.url?scp=84942370813&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942370813&partnerID=8YFLogxK

U2 - 10.1364/BOE.6.000369

DO - 10.1364/BOE.6.000369

M3 - Article

AN - SCOPUS:84942370813

VL - 6

SP - 369

EP - 389

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 2

ER -