Fgf8 signaling for development of the midbrain and hindbrain

Hidekiyo Harada; Tatsuya Sato; Harukazu Nakamura

doi:10.1111/dgd.12293

Fgf8 signaling for development of the midbrain and hindbrain

Hidekiyo Harada, Tatsuya Sato, Harukazu Nakamura

INF - System Information Sciences

Research output: Contribution to journal › Review article › peer-review

25 Citations (Scopus)

Abstract

In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary (MHB), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hindbrain. Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain. Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed.

Original language	English
Pages (from-to)	437-445
Number of pages	9
Journal	Development Growth and Differentiation
Volume	58
Issue number	5
DOIs	https://doi.org/10.1111/dgd.12293
Publication status	Published - 2016 Jun 1

Keywords

Fgf8 signaling
Pea3
Ras-ERK
hindbrain
isthmus
midbrain

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1111/dgd.12293

Cite this

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abstract = "In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary (MHB), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hindbrain. Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain. Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed.",

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AU - Sato, Tatsuya

AU - Nakamura, Harukazu

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Fgf8 signaling for development of the midbrain and hindbrain

Abstract

Keywords

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