Fgf8 signaling for development of the midbrain and hindbrain

Hidekiyo Harada, Tatsuya Sato, Harukazu Nakamura

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)


In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary (MHB), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hindbrain. Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain. Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed.

Original languageEnglish
Pages (from-to)437-445
Number of pages9
JournalDevelopment Growth and Differentiation
Issue number5
Publication statusPublished - 2016 Jun 1


  • Fgf8 signaling
  • Pea3
  • Ras-ERK
  • hindbrain
  • isthmus
  • midbrain

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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