Fgf8 signaling for development of the midbrain and hindbrain

Hidekiyo Harada; Tatsuya Sato; Harukazu Nakamura

doi:10.1111/dgd.12293

Fgf8 signaling for development of the midbrain and hindbrain

Hidekiyo Harada, Tatsuya Sato, Harukazu Nakamura

INF - System Information Sciences

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

Abstract

In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary (MHB), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hindbrain. Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain. Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed.

Original language	English
Pages (from-to)	437-445
Number of pages	9
Journal	Development Growth and Differentiation
Volume	58
Issue number	5
DOIs	https://doi.org/10.1111/dgd.12293
Publication status	Published - 2016 Jun 1

Keywords

Fgf8 signaling
Pea3
Ras-ERK
hindbrain
isthmus
midbrain

ASJC Scopus subject areas

Developmental Biology
Cell Biology

Access to Document

10.1111/dgd.12293

Fingerprint Dive into the research topics of 'Fgf8 signaling for development of the midbrain and hindbrain'. Together they form a unique fingerprint.

Cite this

@article{5dd7b4d9fe9741a79d94dbb6de3acda4,

title = "Fgf8 signaling for development of the midbrain and hindbrain",

abstract = "In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary (MHB), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hindbrain. Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain. Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed.",

keywords = "Fgf8 signaling, Pea3, Ras-ERK, hindbrain, isthmus, midbrain",

author = "Hidekiyo Harada and Tatsuya Sato and Harukazu Nakamura",

year = "2016",

month = jun,

day = "1",

doi = "10.1111/dgd.12293",

language = "English",

volume = "58",

pages = "437--445",

journal = "Development Growth and Differentiation",

issn = "0012-1592",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Fgf8 signaling for development of the midbrain and hindbrain

AU - Harada, Hidekiyo

AU - Sato, Tatsuya

AU - Nakamura, Harukazu

PY - 2016/6/1

Y1 - 2016/6/1

N2 - In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary (MHB), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hindbrain. Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain. Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed.

AB - In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary (MHB), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hindbrain. Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain. Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed.

KW - Fgf8 signaling

KW - Pea3

KW - Ras-ERK

KW - hindbrain

KW - isthmus

KW - midbrain

UR - http://www.scopus.com/inward/record.url?scp=84973531072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973531072&partnerID=8YFLogxK

U2 - 10.1111/dgd.12293

DO - 10.1111/dgd.12293

M3 - Review article

C2 - 27273073

AN - SCOPUS:84973531072

VL - 58

SP - 437

EP - 445

JO - Development Growth and Differentiation

JF - Development Growth and Differentiation

SN - 0012-1592

IS - 5

ER -