Ferulic acid and its water-soluble derivatives inhibit nitric oxide production and inducible nitric oxide synthase expression in rat primary astrocytes

Masaki Kikugawa, Tomoaki Ida, Hideshi Ihara, Tatsuji Sakamoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We recently reported that two water-soluble derivatives of ferulic acid (1-feruloyl glycerol, 1-feruloyl diglycerol) previously developed by our group exhibited protective effects against amyloid-β–induced neurodegeneration in vitro and in vivo. In the current study, we aimed to further understand this process by examining the derivatives’ ability to suppress abnormal activation of astrocytes, the key event of neurodegeneration. We investigated the effects of ferulic acid (FA) derivatives on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in rat primary astrocytes. The results showed that these compounds inhibited NO production and iNOS expression in a concentration-dependent manner and that the mechanism underlying these effects was the suppression of the nuclear factor-κB pathway. This evidence suggests that FA and its derivatives may be effective neuroprotective agents and could be useful in the treatment of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease.

Original languageEnglish
Pages (from-to)1607-1611
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume81
Issue number8
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

Keywords

  • Ferulic acid
  • Ferulic acid derivatives
  • Neuroprotection
  • Nitric oxide

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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