Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats

Ardiansyah, Hitoshi Shirakawa, Puspo E. Giriwono, Kazuki Oguchi, Kazuma Ueda, Hideki Hokazono, Kazuyuki Hiwatashi, Saori Takahashi, Shoko Sato, Michio Komai

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    We studied the effects of fermented barley extract P (FBEP) in stroke-prone spontaneously hypertensive rats (SHRSP). Male 10-week-old SHRSP were divided into three groups that were fed: an AIN-93M diet (control), a low dose of FBEP (4 g/kg; FBEP1), and a high dose of FBEP (20 g/kg; FBEP2) for three weeks. Hypertension was significantly improved by the use of FBEP supplementation. The FBEP diet improved plasma triglyceride, insulin sensitivity, enhanced plasma catalase, and superoxide dismutase activities, and decreased plasma 8-hydroxy-2'-deoxyguanosine levels. In addition, the FBEP diet upregulated hepatic antioxidative genes and modulated Nrf2 protein levels in the liver. Furthermore, a single oral dose of FBEP (2 g/kg body weight) was able to lower blood pressure in SHRSP. In conclusion, our data suggest that increased expression of hepatic antioxidative genes and modulation of Nrf2 may play a role in the regulation of metabolic diseases in SHRSP consuming a FBEP diet.

    Original languageEnglish
    Pages (from-to)1876-1883
    Number of pages8
    JournalBioscience, Biotechnology and Biochemistry
    Volume79
    Issue number11
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Antioxidative
    • Fermented barley extract
    • Hypertension
    • Stroke-prone spontaneously hypertensive rats

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats'. Together they form a unique fingerprint.

    Cite this