TY - JOUR
T1 - Feminizing adrenocortical carcinoma with selective suppression of follicle-stimulating hormone secretion and disorganized steroidogenesis
T2 - A case report and literature review
AU - Saito, Takatoshi
AU - Tojo, Katsuyoshi
AU - Furuta, Nozomu
AU - Ono, Katsuhiko
AU - Sasano, Hironobu
AU - Utsunomiya, Kazunori
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011
Y1 - 2011
N2 - We report a 61-year-old male with gynecomastia, poor libido and erectile dysfunction. Endocrinological studies showed high levels of estradiol and dehydroepiandrosterone sulfate. Although luteinizing hormone (LH) level was within the normal limit, the concentration of follicle-stimulating hormone (FSH) was under the normal limit. Delayed response of LH and poor response of FSH to gonadotropin-releasing hormone administration were detected. Magnetic resonance imaging of the abdomen revealed a left adrenal tumor. Although the surgically-resected tumor was diagnosed as a high grade ACC based on Weiss's criteria of adreno-cortical malignancy, no metastasis was detected. Since estrogen levels normalized after resection, feminizing ACC was confirmed. While LH concentration increased slightly after operation, FSH level became transiently elevated over the normal limit, and finally reached the normal range. These data may suggest that FSH was suppressed selectively by hormone produced by ACC different from estrogen.
AB - We report a 61-year-old male with gynecomastia, poor libido and erectile dysfunction. Endocrinological studies showed high levels of estradiol and dehydroepiandrosterone sulfate. Although luteinizing hormone (LH) level was within the normal limit, the concentration of follicle-stimulating hormone (FSH) was under the normal limit. Delayed response of LH and poor response of FSH to gonadotropin-releasing hormone administration were detected. Magnetic resonance imaging of the abdomen revealed a left adrenal tumor. Although the surgically-resected tumor was diagnosed as a high grade ACC based on Weiss's criteria of adreno-cortical malignancy, no metastasis was detected. Since estrogen levels normalized after resection, feminizing ACC was confirmed. While LH concentration increased slightly after operation, FSH level became transiently elevated over the normal limit, and finally reached the normal range. These data may suggest that FSH was suppressed selectively by hormone produced by ACC different from estrogen.
KW - Estrogen-producing tumor
KW - Feminizing adenocarcinoma
KW - Hyperestrogenemia
UR - http://www.scopus.com/inward/record.url?scp=79960037697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960037697&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.50.4968
DO - 10.2169/internalmedicine.50.4968
M3 - Article
C2 - 21720063
AN - SCOPUS:79960037697
VL - 50
SP - 1419
EP - 1424
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 13
ER -