Fear-enhancing effects of septal oxytocin receptors

Yomayra F. Guzmán, Natalie C. Tronson, Vladimir Jovasevic, Keisuke Sato, Anita L. Guedea, Hiroaki Mizukami, Katsuhiko Nishimori, Jelena Radulovic

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

The nonapeptide oxytocin is considered beneficial to mental health due to its anxiolytic, prosocial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently emerged. Using region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the lateral septum as the brain region mediating fear-enhancing effects of Oxtr. These effects emerge after social defeat and require Oxtr specifically coupled to the extracellular signal-regulated protein kinase pathway.

Original languageEnglish
Pages (from-to)1185-1187
Number of pages3
JournalNature Neuroscience
Volume16
Issue number9
DOIs
Publication statusPublished - 2013 Sep 1

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Guzmán, Y. F., Tronson, N. C., Jovasevic, V., Sato, K., Guedea, A. L., Mizukami, H., Nishimori, K., & Radulovic, J. (2013). Fear-enhancing effects of septal oxytocin receptors. Nature Neuroscience, 16(9), 1185-1187. https://doi.org/10.1038/nn.3465