FcR γ chain deletion results in pleiotrophic effector cell defects

Toshiyuki Takai, Min Li, Diana Sylvestre, Raphael Clynes, Jeffrey V. Ravetch

Research output: Contribution to journalArticlepeer-review

794 Citations (Scopus)

Abstract

The γ subunit of immunoglobulin Fc receptors is an essential component of the high-affinity receptor for IgE (FcεRI) and the low-affinity receptor for IgG (FcγRIII) and is associated with the high-affinity receptor for IgG (FcγRI) and the T cell receptor-CD3 complex. It is required for both receptor assembly and signal transduction. Targeted disruption of this subunit results in immunocompromised mice. Activated macrophages from γ chain-deficient mice unexpectedly lack the ability to phagocytose antibody-coated particles, despite normal binding. Defects in NK cell-mediated antibody-dependent cytotoxicity and mast cell-mediated allergic responses are evident in these animals, establishing the indispensable role of FcRs in these responses. However, loss of γ chain does not appear to perturb T cell development, since both thymic and peripheral T cell populations appear normal. These mice thus represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses.

Original languageEnglish
Pages (from-to)519-529
Number of pages11
JournalCell
Volume76
Issue number3
DOIs
Publication statusPublished - 1994 Feb 11
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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