TY - CHAP
T1 - Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer
AU - Nakamura, Akira
AU - Kubo, Tomohiro
AU - Takai, Toshiyuki
PY - 2008
Y1 - 2008
N2 - Fc receptors (FcRs) play an important role in the maintenance of an adequate activation threshold of various cells in antibody-mediated immune responses. Analyses of murine models show that the inhibitory FcR, FcγRIIB plays a pivotal role in the suppression of antibody-mediated allergy and autoimmunity. On the other hand, the activating-type FcRs are essential for the development of these diseases, suggesting that regulation of inhibitory or activating FcR is an ideal target for a therapeutic agent. Recent experimental or clinical studies also indicate that FcRs function as key receptors in the treatment with monoclonal antibodies (mAbs) therapy. This review summarizes FcR functions and highlights possible FcR-targeting therapies including mAb therapies for allergy, autoimmune diseases and cancer.
AB - Fc receptors (FcRs) play an important role in the maintenance of an adequate activation threshold of various cells in antibody-mediated immune responses. Analyses of murine models show that the inhibitory FcR, FcγRIIB plays a pivotal role in the suppression of antibody-mediated allergy and autoimmunity. On the other hand, the activating-type FcRs are essential for the development of these diseases, suggesting that regulation of inhibitory or activating FcR is an ideal target for a therapeutic agent. Recent experimental or clinical studies also indicate that FcRs function as key receptors in the treatment with monoclonal antibodies (mAbs) therapy. This review summarizes FcR functions and highlights possible FcR-targeting therapies including mAb therapies for allergy, autoimmune diseases and cancer.
UR - http://www.scopus.com/inward/record.url?scp=58149360480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149360480&partnerID=8YFLogxK
U2 - 10.1007/978-0-387-09789-3_17
DO - 10.1007/978-0-387-09789-3_17
M3 - Chapter
C2 - 19065795
AN - SCOPUS:58149360480
SN - 9780387097886
T3 - Advances in Experimental Medicine and Biology
SP - 220
EP - 233
BT - Multichain Immune Recognition Receptor Signaling
A2 - Sigalov, Alexander
ER -