Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer

Akira Nakamura, Tomohiro Kubo, Toshiyuki Takai

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Fc receptors (FcRs) play an important role in the maintenance of an adequate activation threshold of various cells in antibody-mediated immune responses. Analyses of murine models show that the inhibitory FcR, FcγRIIB plays a pivotal role in the suppression of antibody-mediated allergy and autoimmunity. On the other hand, the activating-type FcRs are essential for the development of these diseases, suggesting that regulation of inhibitory or activating FcR is an ideal target for a therapeutic agent. Recent experimental or clinical studies also indicate that FcRs function as key receptors in the treatment with monoclonal antibodies (mAbs) therapy. This review summarizes FcR functions and highlights possible FcR-targeting therapies including mAb therapies for allergy, autoimmune diseases and cancer.

Original languageEnglish
Title of host publicationMultichain Immune Recognition Receptor Signaling
Subtitle of host publicationFrom Spatiotemporal Organization to Human Disease
EditorsAlexander Sigalov
Pages220-233
Number of pages14
DOIs
Publication statusPublished - 2008 Dec 1
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume640
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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