Abstract
Fc receptors (FcRs) play an important role in the maintenance of an adequate activation threshold of various cells in antibody-mediated immune responses. Analyses of murine models show that the inhibitory FcR, FcγRIIB plays a pivotal role in the suppression of antibody-mediated allergy and autoimmunity. On the other hand, the activating-type FcRs are essential for the development of these diseases, suggesting that regulation of inhibitory or activating FcR is an ideal target for a therapeutic agent. Recent experimental or clinical studies also indicate that FcRs function as key receptors in the treatment with monoclonal antibodies (mAbs) therapy. This review summarizes FcR functions and highlights possible FcR-targeting therapies including mAb therapies for allergy, autoimmune diseases and cancer.
| Original language | English |
|---|---|
| Title of host publication | Multichain Immune Recognition Receptor Signaling |
| Subtitle of host publication | From Spatiotemporal Organization to Human Disease |
| Editors | Alexander Sigalov |
| Pages | 220-233 |
| Number of pages | 14 |
| DOIs | |
| Publication status | Published - 2008 Dec 1 |
| Externally published | Yes |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 640 |
| ISSN (Print) | 0065-2598 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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