Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer

Akira Nakamura; Tomohiro Kubo; Toshiyuki Takai

doi:10.1007/978-0-387-09789-3_17

Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer

Akira Nakamura, Tomohiro Kubo, Toshiyuki Takai

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Citations (Scopus)

Abstract

Fc receptors (FcRs) play an important role in the maintenance of an adequate activation threshold of various cells in antibody-mediated immune responses. Analyses of murine models show that the inhibitory FcR, FcγRIIB plays a pivotal role in the suppression of antibody-mediated allergy and autoimmunity. On the other hand, the activating-type FcRs are essential for the development of these diseases, suggesting that regulation of inhibitory or activating FcR is an ideal target for a therapeutic agent. Recent experimental or clinical studies also indicate that FcRs function as key receptors in the treatment with monoclonal antibodies (mAbs) therapy. This review summarizes FcR functions and highlights possible FcR-targeting therapies including mAb therapies for allergy, autoimmune diseases and cancer.

Original language	English
Title of host publication	Multichain Immune Recognition Receptor Signaling
Subtitle of host publication	From Spatiotemporal Organization to Human Disease
Editors	Alexander Sigalov
Pages	220-233
Number of pages	14
DOIs	https://doi.org/10.1007/978-0-387-09789-3_17
Publication status	Published - 2008
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	640
ISSN (Print)	0065-2598

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-0-387-09789-3_17

Cite this

Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer. / Nakamura, Akira; Kubo, Tomohiro; Takai, Toshiyuki.

Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease. ed. / Alexander Sigalov. 2008. p. 220-233 (Advances in Experimental Medicine and Biology; Vol. 640).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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abstract = "Fc receptors (FcRs) play an important role in the maintenance of an adequate activation threshold of various cells in antibody-mediated immune responses. Analyses of murine models show that the inhibitory FcR, FcγRIIB plays a pivotal role in the suppression of antibody-mediated allergy and autoimmunity. On the other hand, the activating-type FcRs are essential for the development of these diseases, suggesting that regulation of inhibitory or activating FcR is an ideal target for a therapeutic agent. Recent experimental or clinical studies also indicate that FcRs function as key receptors in the treatment with monoclonal antibodies (mAbs) therapy. This review summarizes FcR functions and highlights possible FcR-targeting therapies including mAb therapies for allergy, autoimmune diseases and cancer.",

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Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer

Abstract

Publication series

ASJC Scopus subject areas

UN SDGs

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