Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

Shigeaki Hida, Sho Yamasaki, Yuzuru Sakamoto, Masaya Takamoto, Kazushige Obata, Toshiyuki Takai, Hajime Karasuyama, Kazuo Sugane, Takashi Saito, Shinsuke Taki

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The Fc receptor common γ-chain (FcRγ) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcRγ developed normally and proliferated efficiently in response to interleukin 3 (IL-3) but were very impaired in IL-3-induced production of IL-4 and in supporting T helper type 2 differentiation. Through its transmembrane portion, FcRγ associated constitutively with the common β-chain of the IL-3 receptor and signaled by recruiting the kinase Syk. Retrovirus-mediated complementation demonstrated the essential function of the ITAM of FcRγ in IL-3 signal transduction. Our results identify a previously unknown mechanism whereby FcRγ functions to 'route' selective cytokine-triggered signals into the ITAM-mediated IL-4 production pathway.

Original languageEnglish
Pages (from-to)214-222
Number of pages9
JournalNature Immunology
Volume10
Issue number2
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Hida, S., Yamasaki, S., Sakamoto, Y., Takamoto, M., Obata, K., Takai, T., Karasuyama, H., Sugane, K., Saito, T., & Taki, S. (2009). Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nature Immunology, 10(2), 214-222. https://doi.org/10.1038/ni.1686