Membrane receptors for the Fc portions of IgG (Fcγ receptor) and IgM (Fcμ receptor) on leukemic cells in B cell neoplasms in various developmental stages were studied. In 6 out of 7 patients with B-CLL, leukemic cells had both receptors. In macroglobulinemia, leukemic cells had one or the other of Fcγ and Fcμ receptors. In plasma cell leukemia and plasmacytoma, malignant cells had neither Fcγ nor Fcμ receptors. The disappearance of Fc receptors appears to be associated with B cell differentiation.
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