Favorable outcome of unrelated cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia

Yasushi Onishi, Osamu Sasaki, Satoshi Ichikawa, Kyoko Inokura, Yuna Katsuoka, Rie Ohtsuka Ohba, Yoko Okitsu, Katsura Kohata, Hiroto Ohguchi, Noriko Fukuhara, Hisayuki Yokoyama, Minami Fujiwara Yamada, Joji Yamamoto, Kenichi Ishizawa, Junichi Kameoka, Hideo Harigae

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) is one of the highest-risk ALL groups. Whenever possible, patients with Ph+ALL should undergo allogeneic hematopoietic stem cell transplantation (HSCT) after induction of remission. Although unrelated cord blood transplantation (CBT) has become a common treatment in adult patients who lack a sibling donor, data on the efficacy of CBT for Ph+ALL are limited. We analyzed the clinical outcomes of 20 Ph+ALL patients who underwent CBT (n = 8) or unrelated bone marrow transplantation (BMT) (n = 12). The median age was 41 years (range, 17-55 years). All but one of the patients were treated with an imatinib-based regimen before HSCT, and 19 patients were in first complete remission (CR) and 1 patient was in second CR at the time of HSCT. Seventeen patients received a myeloablative conditioning regimen containing 12 Gy of total-body irradiation, and 3 received a reduced-intensity conditioning regimen. After a median of 26 months of follow-up, estimated 3-year overall and leukemia-free survival rates were 100% and 85%, respectively, after CBT, and 49% and 38%, respectively, after unrelated BMT. The CBT group had significantly better overall survival than the BMT group (P = .02). Although BCR-ABL transcript was detected in 4 of 8 CBT patients at transplantation, 7 patients remained in molecular CR. Our findings suggest that CBT may be a viable option as postinduction therapy for Ph+ALL in patients lacking a sibling donor.

Original languageEnglish
Pages (from-to)1093-1097
Number of pages5
JournalBiology of Blood and Marrow Transplantation
Volume17
Issue number7
DOIs
Publication statusPublished - 2011 Jul

Keywords

  • CBT
  • Imatinib
  • Ph+ALL
  • Tyrosine kinase inhibitor
  • Unrelated bone marrow transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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