Fatty acid-binding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung

Shuhan Yang, Shuhei Kobayashi, Kaname Sekino, Yoshiteru Kagawa, Hirofumi Miyazaki, Subrata Kumar Shil, Banlanjo Abdulaziz Umaru, Tunyanat Wannakul, Yuji Owada

Research output: Contribution to journalArticlepeer-review

Abstract

Fatty acid-binding protein (FABP) 5 is highly expressed in various types of tumors and is strongly correlated with tumor growth, development, and metastasis. However, it is unclear how the expression of FABP5 in the host affects tumor progression. In this study, using a lung tumor metastasis model in mice, we found that FABP5-deficient mice were more susceptible to tumor metastasis, which is accompanied by infiltration of a lower frequency of activated natural killer (NK) cells in the lung. Additionally, FABP5 deficiency leads to impaired maturation of NK cells in the lungs, but not in the bone marrow and spleen. Taken together, our results provide the first evidence that FABP5 in the host regulates lung tumor metastasis through controlling NK cell maturation.

Original languageEnglish
Pages (from-to)1797-1805
Number of pages9
JournalFEBS Letters
Volume595
Issue number13
DOIs
Publication statusPublished - 2021 Jul
Externally publishedYes

Keywords

  • FABP
  • NK cell maturation
  • tumor metastasis

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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