Fatty acid-binding protein 3 regulates differentiation of IgM-producing plasma cells

Shuhei Kobayashi, Hai The Phung, Shunichi Tayama, Yoshiteru Kagawa, Hirofumi Miyazaki, Yui Yamamoto, Takashi Maruyama, Naoto Ishii, Yuji Owada

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma cells (PCs), which aim to protect host health, produce various subsets of immunoglobulin (Ig) in response to extracellular pathogens. Blimp-1 (encoded by Prdm1)—a protein that is highly expressed by PCs—is important for PC functions, including the generation of Igs. Fatty acid-binding protein 3 (FABP3) is a carrier protein of polyunsaturated fatty acids (PUFAs) and participates in multiple cellular functions. Although the functions of FABP3 in neurons and cardiac myocytes are well-noted, their roles in immune cells remain to be fully elucidated. In this study, we demonstrate that FABP3 is expressed in activated B cells and that FABP3 promotes PC development and IgM secretion. Moreover, we provide the first evidence that FABP3 is necessary for Blimp-1 expression, by regulating the histone modification of its promoter region. Taken together, our findings reveal that FABP3 acts as a positive regulator of B-cell activation by controlling histone acetylation of the Blimp-1 gene, thereby playing a role in host defense against pathogens.

Original languageEnglish
Pages (from-to)1130-1141
Number of pages12
JournalFEBS Journal
Volume288
Issue number4
DOIs
Publication statusPublished - 2021 Feb

Keywords

  • Blimp-1
  • FABP3
  • histone acetylation
  • plasma cell

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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