Fate mapping of the mouse prosencephalic neural plate

Takayoshi Inoue, Shun Nakamura, Noriko Osumi

Research output: Contribution to journalArticlepeer-review

142 Citations (Scopus)

Abstract

Little is known about the behavior of cells within the anterior neural plate or tube in developing mammalian embryos in utero due to technical limitations. Here we labeled neuroepithelial cells with vital dye and traced their siblings for 1 or 2 days using the whole-embryo culture system. The results demonstrated that rostral cell movement from the midbrain to the forebrain in the mouse neural plate was restricted at the boundary by the five-somite stage. Coincident with restriction of cell intermingling, expression of a transcription factor, Pax6, and a cell adhesion molecule, cadherin-6, commmenced to demarcate the forebrain compartment. Within this compartment, we also mapped several prospective regions of the telencephalon and diencephalon to the eyes. The fate map of the mouse prosencephalic neural plate was very similar to those of other vertebrates, providing evidence that mammalian-specific brain structures, represented in the cerebral neocortex, could evenly develop along the conserved framework of neuromeres. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)373-383
Number of pages11
JournalDevelopmental Biology
Volume219
Issue number2
DOIs
Publication statusPublished - 2000 Mar 15

Keywords

  • Cadherin-6
  • Compartment
  • Fate mapping
  • Mammalian whole embryo culture
  • Mouse forebrain
  • Neural crest cells
  • Neuromeres
  • Pax6

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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