Fatal hepatic failure associated with graft rejection following reduced-intensity stem-cell transplantation for chronic idiopathic myelofibrosis (CIMF)

Shigesaburo Miyakoshi, Masahiro Kami, Yukiko Kishi, Naoko Murashige, Koichiro Yuji, Eiji Kusumi, Tomoko Matsumura, Yasushi Onishi, Kazuhiko Kobayashi, Sung Won Kim, Tamae Hamaki, Yoichi Takaue, Shuichi Taniguchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A 54-year-old man with chronic idiopathic myelofibrosis (CIMF) underwent RIST. His clinical course had been uneventful until day 60, when splenomegaly reappeared. Hepatic dysfunction developed on day 75. Recipient-type hematopoiesis increased to 51% on day 90. After rapid tapering of cyclosporin, serum levels of AST and ALP normalized in parallel with recovery of complete chimerism on day 134. Yet, jaundice progressed. He died of liver failure on day 176. Postmortem examination revealed neither GVHD nor VOD. Graft rejection following RIST for CIMF may lead to fatal hepatic damage through extramedullary hematopoiesis in the liver or cytokine-mediated immune dysregulations.

Original languageEnglish
Pages (from-to)2513-2516
Number of pages4
JournalLeukemia and Lymphoma
Volume45
Issue number12
DOIs
Publication statusPublished - 2004 Dec
Externally publishedYes

Keywords

  • Allogeneic hematopoietic stem-cell transplantation
  • Extramedullary hematopoiesis
  • Graft failure
  • Graft-vs.-host disease
  • Hepatic venoocclusive disease

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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