Fatal hemorrhage after radiochemotherapy for leptomeningeal dissemination of glioma: Report of two cases

Ryuta Saito; Toshihiro Kumabe; Hidefumi Jokura; Takashi Yoshimoto

doi:10.1016/S0090-3019(01)00605-X

Fatal hemorrhage after radiochemotherapy for leptomeningeal dissemination of glioma: Report of two cases

Ryuta Saito, Toshihiro Kumabe, Hidefumi Jokura, Takashi Yoshimoto

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

BACKGROUND: Dissemination of malignant gliomas is often observed, but the treatment of choice for leptomeningeal dissemination has not been established. CASE DESCRIPTIONS: A 55-year-old man suffered fatal hemorrhage 1 day after whole brain irradiation (2 Gy) along with intravenous administration of 150 mg of nitrosourea (ACNU) for leptomeningeal dissemination of glioblastoma. A 14-year-old boy suffered hemorrhage after intrathecal administration of 10 mg of methotrexate for recurrence of leptomeningeal dissemination of anaplastic astrocytoma 4 months after local brain irradiation and ACNU administration, and died 19 days later. CONCLUSION: Massive fatal hemorrhage is an unusual but possible acute complication after radiochemotherapy for leptomeningeal dissemination of gliomas.

Original language	English
Pages (from-to)	46-48
Number of pages	3
Journal	Surgical Neurology
Volume	57
Issue number	1
DOIs	https://doi.org/10.1016/S0090-3019(01)00605-X
Publication status	Published - 2002

Keywords

Fatal hemorrhage
Glioma
Intrathecal
Leptomeningeal dissemination
Methotrexate
Radiation

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/S0090-3019(01)00605-X

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Cite this

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abstract = "BACKGROUND: Dissemination of malignant gliomas is often observed, but the treatment of choice for leptomeningeal dissemination has not been established. CASE DESCRIPTIONS: A 55-year-old man suffered fatal hemorrhage 1 day after whole brain irradiation (2 Gy) along with intravenous administration of 150 mg of nitrosourea (ACNU) for leptomeningeal dissemination of glioblastoma. A 14-year-old boy suffered hemorrhage after intrathecal administration of 10 mg of methotrexate for recurrence of leptomeningeal dissemination of anaplastic astrocytoma 4 months after local brain irradiation and ACNU administration, and died 19 days later. CONCLUSION: Massive fatal hemorrhage is an unusual but possible acute complication after radiochemotherapy for leptomeningeal dissemination of gliomas.",

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author = "Ryuta Saito and Toshihiro Kumabe and Hidefumi Jokura and Takashi Yoshimoto",

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T2 - Report of two cases

AU - Saito, Ryuta

AU - Kumabe, Toshihiro

AU - Jokura, Hidefumi

AU - Yoshimoto, Takashi

PY - 2002

Y1 - 2002

N2 - BACKGROUND: Dissemination of malignant gliomas is often observed, but the treatment of choice for leptomeningeal dissemination has not been established. CASE DESCRIPTIONS: A 55-year-old man suffered fatal hemorrhage 1 day after whole brain irradiation (2 Gy) along with intravenous administration of 150 mg of nitrosourea (ACNU) for leptomeningeal dissemination of glioblastoma. A 14-year-old boy suffered hemorrhage after intrathecal administration of 10 mg of methotrexate for recurrence of leptomeningeal dissemination of anaplastic astrocytoma 4 months after local brain irradiation and ACNU administration, and died 19 days later. CONCLUSION: Massive fatal hemorrhage is an unusual but possible acute complication after radiochemotherapy for leptomeningeal dissemination of gliomas.

AB - BACKGROUND: Dissemination of malignant gliomas is often observed, but the treatment of choice for leptomeningeal dissemination has not been established. CASE DESCRIPTIONS: A 55-year-old man suffered fatal hemorrhage 1 day after whole brain irradiation (2 Gy) along with intravenous administration of 150 mg of nitrosourea (ACNU) for leptomeningeal dissemination of glioblastoma. A 14-year-old boy suffered hemorrhage after intrathecal administration of 10 mg of methotrexate for recurrence of leptomeningeal dissemination of anaplastic astrocytoma 4 months after local brain irradiation and ACNU administration, and died 19 days later. CONCLUSION: Massive fatal hemorrhage is an unusual but possible acute complication after radiochemotherapy for leptomeningeal dissemination of gliomas.

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KW - Leptomeningeal dissemination

KW - Methotrexate

KW - Radiation

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