Fatal hemorrhage after radiochemotherapy for leptomeningeal dissemination of glioma: Report of two cases

Ryuta Saito, Toshihiro Kumabe, Hidefumi Jokura, Takashi Yoshimoto

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

BACKGROUND: Dissemination of malignant gliomas is often observed, but the treatment of choice for leptomeningeal dissemination has not been established. CASE DESCRIPTIONS: A 55-year-old man suffered fatal hemorrhage 1 day after whole brain irradiation (2 Gy) along with intravenous administration of 150 mg of nitrosourea (ACNU) for leptomeningeal dissemination of glioblastoma. A 14-year-old boy suffered hemorrhage after intrathecal administration of 10 mg of methotrexate for recurrence of leptomeningeal dissemination of anaplastic astrocytoma 4 months after local brain irradiation and ACNU administration, and died 19 days later. CONCLUSION: Massive fatal hemorrhage is an unusual but possible acute complication after radiochemotherapy for leptomeningeal dissemination of gliomas.

Original languageEnglish
Pages (from-to)46-48
Number of pages3
JournalSurgical Neurology
Volume57
Issue number1
DOIs
Publication statusPublished - 2002

Keywords

  • Fatal hemorrhage
  • Glioma
  • Intrathecal
  • Leptomeningeal dissemination
  • Methotrexate
  • Radiation

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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