Abstract
BACKGROUND: Dissemination of malignant gliomas is often observed, but the treatment of choice for leptomeningeal dissemination has not been established. CASE DESCRIPTIONS: A 55-year-old man suffered fatal hemorrhage 1 day after whole brain irradiation (2 Gy) along with intravenous administration of 150 mg of nitrosourea (ACNU) for leptomeningeal dissemination of glioblastoma. A 14-year-old boy suffered hemorrhage after intrathecal administration of 10 mg of methotrexate for recurrence of leptomeningeal dissemination of anaplastic astrocytoma 4 months after local brain irradiation and ACNU administration, and died 19 days later. CONCLUSION: Massive fatal hemorrhage is an unusual but possible acute complication after radiochemotherapy for leptomeningeal dissemination of gliomas.
Original language | English |
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Pages (from-to) | 46-48 |
Number of pages | 3 |
Journal | Surgical Neurology |
Volume | 57 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2002 |
Keywords
- Fatal hemorrhage
- Glioma
- Intrathecal
- Leptomeningeal dissemination
- Methotrexate
- Radiation
ASJC Scopus subject areas
- Surgery
- Clinical Neurology