Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: Experimental study in rats using vascular corrosion casts

Hany Eldawoody, Hiroaki Shimizu, Naoto Kimura, Atsushi Saito, Toshio Nakayama, Akira Takahashi, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Fasudil (a Rho-kinase inhibitor) has been shown to attenuate abdominal aortic aneurysm development, but any preventive effect against development of cerebral aneurysms is unclear. The effect of fasudil on the development of cerebral aneurysms was investigated in 55 female Sprague-Dawley rats divided into 4 groups: Group 1 (n = 10) was the control group without treatment. Groups 2-4 (n = 15 each) were subjected to cerebral aneurysm induction procedures plus 1% NaCl in the drinking water. Groups 3 and 4 were also treated with 0.5 or 1.0 mg/mL of fasudil in the drinking water, respectively. Vascular corrosion casts of the cerebral arteries were prepared and examined using a scanning electron microscope after 2 months. No significant differences were observed in the degree of induced hypertension between Groups 2, 3 and 4. No aneurysms were found in Group 1. Examination of the left anterior cerebral-olfactory artery junction, which is the most susceptible site for aneurysm development, found significantly fewer aneurysmal lesions in Groups 3 (60%) and 4 (53%) compared to Group 2 (100%) (P < 0.02). This study suggests that fasudil attenuated induction of cerebral aneurysms in the rat model.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalNeuroscience Letters
Volume470
Issue number1
DOIs
Publication statusPublished - 2010 Feb 5

Keywords

  • Cerebral aneurysm
  • Experimental
  • Fasudil
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: Experimental study in rats using vascular corrosion casts'. Together they form a unique fingerprint.

Cite this