False positive reactivity of a substance P-antibody in the ectodermal/epithelial plug of the nose, ear, eye and perineum of the human and mouse fetuses

Hiroshi Masumoto, Yukio Katori, Tetsuaki Kawase, Baik Hwan Cho, Gen Murakami, Shunichi Shibata, Akio Matsubara

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The main aim of this review is (1) to introduce the two previous studies we published human lower limb anatomy based on the conventional macroscopic anatomical criteria with hazardous recognition of this description, (2) to activate the discussion whether the limb homology exists, and (3) to contribute to future study filling the gap between the gross anatomy and embryology. One of the topic we discussed was the human persistent sciatic artery. To date, numerous human cases of persistent sciatic artery have been reported in which the anomalous artery was present in the posterior compartment of the thigh alongside the sciatic nerve. As one of the important criteria for assessing the human primitive sciatic artery, its ventral arterial position with respect to the sciatic nerve is reasonable based on the initial positional relationship between ventral arterial and dorsal nervous system and comparative anatomical findings. We also discuss ways of considering the topography of muscles of the lower limb and their innervations compared to those of the upper limb. We propose a schema of the complex anatomical characteristics of the lower limb based on the vertebrate body plan. According to this reasonable schema, the twisted anatomy of the lower limb can be understood more easily. These two main ideas discussed in this paper will be useful for further understanding of the anatomy of the lower limb and as a sirst step for future. We hope that the future study in lower limb will be further developed by both viewpoints of the classical gross anatomy and recent embryology.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalOkajimas Folia Anatomica Japonica
Volume87
Issue number2
DOIs
Publication statusPublished - 2010 Dec 1

Keywords

  • Auditory meatal plug
  • False positive reaction
  • Fetal prepuce
  • Nasal plug
  • Substance P

ASJC Scopus subject areas

  • Anatomy

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