False item recognition in patients with Alzheimer's disease

Nobuhito Abe, Toshikatsu Fujii, Yoshiyuki Nishio, Osamu Iizuka, Shigenori Kanno, Hirokazu Kikuchi, Masahito Takagi, Kotaro Hiraoka, Hiroshi Yamasaki, Hyunjoo Choi, Kazumi Hirayama, Mayumi Shinohara, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Recent evidence suggests that patients with Alzheimer's disease (AD), as compared with normal individuals, exhibit increased false recognition by stimulus repetition in the Deese-Roediger-McDermott (DRM) task or associative recognition memory tasks, probably due to impaired recollection-based monitoring. However, because of possible alternative explanations for the findings of these previous studies, the evidence for impaired recollection-based monitoring in AD patients remains inconclusive. In this study, we employed stimulus repetition in old/new recognition judgments of single-item picture memory without a factor of association between the stimuli and examined whether AD patients showed increased false item recognition as compared with healthy controls. AD patients and healthy controls studied single-item pictures presented either once or three times. They were later asked to make an old/new recognition judgment in response to (a) Same pictures, pictures identical to those seen at encoding, (b) Similar lures, novel pictures similar to but not identical to those seen at encoding, and (c) Dissimilar lures, novel pictures not similar to those seen at encoding. For Same pictures, repeated presentation of stimuli increased the proportion of "old" responses in both groups. For Similar lures, repeated presentation of stimuli increased the rate of "old" responses in AD patients but not in control subjects. The results of the present study clearly demonstrated elevated false recognition by stimulus repetition in single-item recognition in AD patients. The present findings strongly support the view that AD patients are impaired in their ability to use item-specific recollection in order to avoid false recognition.

Original languageEnglish
Pages (from-to)1897-1902
Number of pages6
JournalNeuropsychologia
Volume49
Issue number7
DOIs
Publication statusPublished - 2011 Jun

Keywords

  • Alzheimer's disease
  • Familiarity
  • Memory
  • Recognition
  • Recollection

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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