Factors influencing pulmonary surfactant protein A levels in cord blood, maternal blood and amniotic fluid

Kazutoshi Cho, Tadashi Matsuda, Satoru Okajima, Yoshinori Matsumoto, Tadashi Sagawa, Seiichiro Fujimoto, Kunihiko Kobayashi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The purpose of this study was to evaluate factors that influence pulmonary surfactant protein A (SP-A) levels in cord blood, maternal blood and amniotic fluid, as well as to establish the normal range of serum SP-A. Labor significantly influenced cord blood SPA levels. The SP-A levels in maternal blood after delivery were correlated with, but higher than those before delivery. There was a correlation between SP-A levels in amniotic fluid and cord blood. Neonatal serum SP-A was not correlated with maternal SP-A levels. The normal range of SP-A in cord blood was 2.7-21.7 ng/ml following cesarean section without labor, 4.8-50.2 ng/ml after labor at gestational weeks 36-38, and 12.2-44.6 ng/ml at gestational weeks 39-41. SP-A levels in maternal blood before and after delivery and amniotic fluid were 6.0-74.0, 9.6-73.6 and 403.4-24,540 ng/ml, respectively.

Original languageEnglish
Pages (from-to)104-110
Number of pages7
JournalBiology of the Neonate
Volume75
Issue number2
DOIs
Publication statusPublished - 1999 Feb

Keywords

  • Amniotic fluid
  • Cord blood
  • Maternal blood
  • Pulmonary surfactant protein A, normal range

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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  • Cite this

    Cho, K., Matsuda, T., Okajima, S., Matsumoto, Y., Sagawa, T., Fujimoto, S., & Kobayashi, K. (1999). Factors influencing pulmonary surfactant protein A levels in cord blood, maternal blood and amniotic fluid. Biology of the Neonate, 75(2), 104-110. https://doi.org/10.1159/000014085