Factors associated with psychotic symptoms in Alzheimer's disease

Nobutsugu Hirono, Etsuro Mori, Minoru Yasuda, Yoshitaka Ikejiri, Toru Imamura, Tatsuo Shimomura, Manabu Ikeda, Mamoru Hashimoto, Hikari Yamashita

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

Objectives - Many clinical and biological factors have been reported to be associated with the presence of psychosis in patients with Alzheimer's disease, although the associations were variable. The aim of this study was to clarify factors associated with the presence of psychosis in patients with Alzheimer's disease. Methods - Psychiatric functioning was studied in 228 patients with Alzheimer's disease based on the results of the behavioural pathology in Alzheimer's disease rating scale or the neuropsychiatric inventory. The effects of sex, education level, age, duration of illness, cognitive function, and apolipoprotein E genotype were investigated for dichotomous psychotic status with a multiple logistic regression analysis. Results - Of the 228 patients with Alzheimer's disease, 118 (51.8%) showed evidence of delusions or hallucinations. Of these, 94 had delusions only, three had hallucinations only and 21 had both. Older age, female sex, longer duration of illness, and more severe cognitive impairment were the factors independently associated with the presence of psychosis. The presence of psychosis was not significantly related to either educational level or apolipoprotein E genotype. Conclusions - Age, sex, and severity of illness were independent factors associated with the presence of psychosis in patients with Alzheimer's disease. The reason why some patients with Alzheimer's disease develop psychosis remains unclear. There may be distinctive subtypes of Alzheimer's disease or the presence of individual factors which affect the development of psychosis.

Original languageEnglish
Pages (from-to)648-652
Number of pages5
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume64
Issue number5
DOIs
Publication statusPublished - 1998 May

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Psychotic symptoms

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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