Facilely accessible multidrug resistance modulator derived from sucrose

Nobutoshi Murakami, Satoru Tamura, Etsuko Iwata, Shunji Aoki, Shin ichi Akiyama, Motomasa Kobayashi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3′,4′-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.

Original languageEnglish
Pages (from-to)3267-3270
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number22
DOIs
Publication statusPublished - 2002 Nov 18

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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