TY - JOUR
T1 - Facilely accessible multidrug resistance modulator derived from sucrose
AU - Murakami, Nobutoshi
AU - Tamura, Satoru
AU - Iwata, Etsuko
AU - Aoki, Shunji
AU - Akiyama, Shin ichi
AU - Kobayashi, Motomasa
N1 - Funding Information:
This study was financially supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan. The authors are also grateful to the Naito Foundation, the Hoh-ansha Foundation, and the San-Ei Gen Foundation for Food Chemical Research for financial support.
PY - 2002/11/18
Y1 - 2002/11/18
N2 - Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3′,4′-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.
AB - Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3′,4′-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.
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U2 - 10.1016/S0960-894X(02)00702-3
DO - 10.1016/S0960-894X(02)00702-3
M3 - Article
C2 - 12392729
AN - SCOPUS:0037131760
VL - 12
SP - 3267
EP - 3270
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 22
ER -