Abstract
Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3′,4′-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.
Original language | English |
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Pages (from-to) | 3267-3270 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 12 |
Issue number | 22 |
DOIs | |
Publication status | Published - 2002 Nov 18 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry