Facilely accessible multidrug resistance modulator derived from sucrose

Nobutoshi Murakami; Satoru Tamura; Etsuko Iwata; Shunji Aoki; Shin ichi Akiyama; Motomasa Kobayashi

doi:10.1016/S0960-894X(02)00702-3

Facilely accessible multidrug resistance modulator derived from sucrose

Nobutoshi Murakami, Satoru Tamura, Etsuko Iwata, Shunji Aoki, Shin ichi Akiyama, Motomasa Kobayashi

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3′,4′-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.

Original language	English
Pages (from-to)	3267-3270
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	22
DOIs	https://doi.org/10.1016/S0960-894X(02)00702-3
Publication status	Published - 2002 Nov 18

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(02)00702-3

Fingerprint Dive into the research topics of 'Facilely accessible multidrug resistance modulator derived from sucrose'. Together they form a unique fingerprint.

Cite this

@article{7e7c8bcf4bb74b42a5247eecc0337a0c,

title = "Facilely accessible multidrug resistance modulator derived from sucrose",

abstract = "Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3′,4′-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.",

author = "Nobutoshi Murakami and Satoru Tamura and Etsuko Iwata and Shunji Aoki and Akiyama, {Shin ichi} and Motomasa Kobayashi",

year = "2002",

month = nov,

day = "18",

doi = "10.1016/S0960-894X(02)00702-3",

language = "English",

volume = "12",

pages = "3267--3270",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "22",

}

TY - JOUR

T1 - Facilely accessible multidrug resistance modulator derived from sucrose

AU - Murakami, Nobutoshi

AU - Tamura, Satoru

AU - Iwata, Etsuko

AU - Aoki, Shunji

AU - Akiyama, Shin ichi

AU - Kobayashi, Motomasa

PY - 2002/11/18

Y1 - 2002/11/18

N2 - Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3′,4′-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.

AB - Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3′,4′-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.

UR - http://www.scopus.com/inward/record.url?scp=0037131760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037131760&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(02)00702-3

DO - 10.1016/S0960-894X(02)00702-3

M3 - Article

C2 - 12392729

AN - SCOPUS:0037131760

VL - 12

SP - 3267

EP - 3270

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 22

ER -