Facile synthesis of 2-substituted indoles from o-bromoaniline

Takao Sakamoto, Yoshinori Kondo, Hiroshi Yamanaka

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The condensation of ethyl o-bromocarbanilate (4) with trimethylsilylacetylene in the presence of dichlorobis(tri-phenylphosphine) palladium, followed by treatment with sodium ethoxide in boiling ethanol gave indole (3a) in 72 % overall yield from 4. Similarly, 2-substituted indoles (3b,c) were synthesized from 4 and the corresponding 1-alkynes.

Original languageEnglish
Pages (from-to)31-32
Number of pages2
JournalHeterocycles
Volume24
Issue number1
Publication statusPublished - 1986 Jan 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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