Abstract
The condensation of ethyl o-bromocarbanilate (4) with trimethylsilylacetylene in the presence of dichlorobis(tri-phenylphosphine) palladium, followed by treatment with sodium ethoxide in boiling ethanol gave indole (3a) in 72 % overall yield from 4. Similarly, 2-substituted indoles (3b,c) were synthesized from 4 and the corresponding 1-alkynes.
| Original language | English |
|---|---|
| Pages (from-to) | 31-32 |
| Number of pages | 2 |
| Journal | Heterocycles |
| Volume | 24 |
| Issue number | 1 |
| Publication status | Published - 1986 Jan 1 |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry
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Sakamoto, T., Kondo, Y., & Yamanaka, H. (1986). Facile synthesis of 2-substituted indoles from o-bromoaniline. Heterocycles, 24(1), 31-32.