Facile preparation of N-acylsulfonamides by using sulfonyl isocyanate

Shino Manabe, Tomoyuki Sugioka, Yukishige Ito

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


N-Acylsulfonamide is widely used as a carboxylic acid bioisostere. A rapid and mild acyl sulfonamide preparation methodology from carboxylic acid and arylsulfonyl isocyanate in the presence of amine is described. The preparation of biologically active acylsulfonamide by our methodology is also presented.

Original languageEnglish
Pages (from-to)787-789
Number of pages3
JournalTetrahedron Letters
Issue number5
Publication statusPublished - 2007 Jan 29
Externally publishedYes


  • Carboxylic acid isostere
  • N-Acylsulfonamide
  • Sulfonyl isocyanate

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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