Facile Preparation of 6-Bromopyridine-2-carboxamide and Pyridine-2,6-dicarboxamide: Partial Aminocarbonylation of 2,6-Dibromopyridine

Hiroshi Horino, Hiroyuki Sakaba, Mannosuke Arai

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The palladium-catalyzed carbonylation of 2,6-dibromopyridine in the presence of primary amines under controlled conditions (carbon monoxide pressure) gives mainly N-aryl- or N-alkyl-6-bromopyridine-2-carboxamides accompanied by N,N′-diaryl- or N,N′-dialkylpyridine- 2,6-dicarboxamides. Further aminocarbonylation of the N-aryl- and N- alkyl-6-bromopyridine-2-carboxamides affords unsymmetric N,N′- diaryl, N-alkyl-N′-aryl-, or N,N′-dialkylpyridine-2,6-dicarboxamides.

Original languageEnglish
Pages (from-to)715-718
Number of pages4
JournalSynthesis (Germany)
Volume1989
Issue number9
DOIs
Publication statusPublished - 1989 Jan 1

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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