Abstract
The combination of 1,4-benzoquinone and a catalytic amount of NaI was found to be effective for the deprotection of dithioacetals. The reactions proceeded efficiently under mild, near-neutral reaction conditions, producing a wide range of aryl and alkyl aldehydes and ketones generally in high yields with good functional group compatibility. The method developed therefore represents a general, facile, and highly applicable approach for deprotecting dithioacetals.
Original language | English |
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Pages (from-to) | 9192-9199 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 69 |
Issue number | 44 |
DOIs | |
Publication status | Published - 2013 Nov 4 |
Externally published | Yes |
Keywords
- 1,3-Dithianes
- Aldehydes
- Deprotection
- Desulfurization
- Ketones
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry