Fabrication of yttria microcapsules for radiotherapy from water/oil emulsion

Toshiki Miyazaki, Tomohiro Kai, Eiichi Ishida, Masakazu Kawashita, Masahiro Hiraoka

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Radiotherapy using ceramic microparticles that act as β-emitters after neutron bombardment is attractive as a minimally invasive option for cancer treatment. Yttria (Y2O3) microcapsules (2030μm in diameter) are capable of cutting off the nutrition supply in cancer cells through an embolization effect. In the present study, Y2O3 microcapsules were prepared via precipitation of yttrium hydroxide from a water/oil (W/O) emulsion and a subsequent heat treatment. The emulsion was prepared by dispersing yttrium hydroxide sol in 2-ethyl-1-hexanol. Microcapsules were obtained by an addition of the emulsion in butanol via dehydration and subsequent aggregation of the yttrium hydroxide. The effects of the rotation speed and surfactant concentration on the diameter of the particles were investigated. The diameter of the microcapsules showed a tendency to decrease with increases in rotation speed during emulsion preparation or surfactant concentration in the oil phase. A high yield of the Y2O3 microcapsules with a diameter of 2030μm were obtained after a heat treatment at the optimized rotation speed and surfactant concentration. The obtained microcapsules showed high chemical durability in a simulated body environment.

Original languageEnglish
Pages (from-to)479-482
Number of pages4
JournalJournal of the Ceramic Society of Japan
Volume118
Issue number1378
DOIs
Publication statusPublished - 2010 Jun

Keywords

  • Emulsion
  • Microcapsule
  • Radiotherapy
  • Sol-gel
  • Yttria (YO)

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry

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