Fabrication of size-controlled SN-38 pure drug nanocrystals through an ultrasound-assisted reprecipitation method toward efficient drug delivery for cancer treatment

Yoshitaka Koseki, Yoshikazu Ikuta, Farsai Taemaitree, Nozomi Saito, Ryuju Suzuki, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

Research output: Contribution to journalArticlepeer-review

Abstract

Carrier-free drug nanoparticles are a promising drug delivery system for cancer therapy; however, the fabrication of nanoparticles composed of small molecule drugs is challenging. In this study, we fabricated pure drug nanocrystals, with nearly 100% of 7-ethyl-10-hydroxycamptothecin (SN-38) molecules, by using the ultrasound-assisted reprecipitation method. The rod-like nanocrystals with ca. 150 nm in a long axis were obtained through the ultrasound-assisted reprecipitation method, and the nanofibers were obtained without irradiation. Furthermore, the SN-38 nanocrystals exhibited considerably higher cytostatic activity against cancer cells than irinotecan hydrochloride, which is a clinically used prodrug of SN-38. These results demonstrate the potential of the ultrasound-assisted precipitation method as a powerful process to fabricate nanoparticles assembled using only small molecule drugs.

Original languageEnglish
Article number126265
JournalJournal of Crystal Growth
Volume572
DOIs
Publication statusPublished - 2021 Oct 15

Keywords

  • A1. Ultrasound irradiation
  • B1. SN-38
  • B2. Pure drug nanocrystals
  • B3. Cancer therapy
  • B3. Drug delivery system

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Inorganic Chemistry
  • Materials Chemistry

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