TY - JOUR
T1 - Fabrication of size-controlled SN-38 pure drug nanocrystals through an ultrasound-assisted reprecipitation method toward efficient drug delivery for cancer treatment
AU - Koseki, Yoshitaka
AU - Ikuta, Yoshikazu
AU - Taemaitree, Farsai
AU - Saito, Nozomi
AU - Suzuki, Ryuju
AU - Dao, Anh Thi Ngoc
AU - Onodera, Tsunenobu
AU - Oikawa, Hidetoshi
AU - Kasai, Hitoshi
N1 - Funding Information:
We would like to thank Dr. Hiroshi Yabu of IMRAM, Tohoku University, who established the in vitro experiment. This study was supported by JSPS Grants-in-Aid for Scientific Research (No. 19K15690 and No. 19H02785), the Cooperative Research Program of “Network Joint Research Center for Materials and Devices”, and the Research Program of “Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials” in “Network Joint Research Center for Materials and Devices”.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/10/15
Y1 - 2021/10/15
N2 - Carrier-free drug nanoparticles are a promising drug delivery system for cancer therapy; however, the fabrication of nanoparticles composed of small molecule drugs is challenging. In this study, we fabricated pure drug nanocrystals, with nearly 100% of 7-ethyl-10-hydroxycamptothecin (SN-38) molecules, by using the ultrasound-assisted reprecipitation method. The rod-like nanocrystals with ca. 150 nm in a long axis were obtained through the ultrasound-assisted reprecipitation method, and the nanofibers were obtained without irradiation. Furthermore, the SN-38 nanocrystals exhibited considerably higher cytostatic activity against cancer cells than irinotecan hydrochloride, which is a clinically used prodrug of SN-38. These results demonstrate the potential of the ultrasound-assisted precipitation method as a powerful process to fabricate nanoparticles assembled using only small molecule drugs.
AB - Carrier-free drug nanoparticles are a promising drug delivery system for cancer therapy; however, the fabrication of nanoparticles composed of small molecule drugs is challenging. In this study, we fabricated pure drug nanocrystals, with nearly 100% of 7-ethyl-10-hydroxycamptothecin (SN-38) molecules, by using the ultrasound-assisted reprecipitation method. The rod-like nanocrystals with ca. 150 nm in a long axis were obtained through the ultrasound-assisted reprecipitation method, and the nanofibers were obtained without irradiation. Furthermore, the SN-38 nanocrystals exhibited considerably higher cytostatic activity against cancer cells than irinotecan hydrochloride, which is a clinically used prodrug of SN-38. These results demonstrate the potential of the ultrasound-assisted precipitation method as a powerful process to fabricate nanoparticles assembled using only small molecule drugs.
KW - A1. Ultrasound irradiation
KW - B1. SN-38
KW - B2. Pure drug nanocrystals
KW - B3. Cancer therapy
KW - B3. Drug delivery system
UR - http://www.scopus.com/inward/record.url?scp=85111798829&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85111798829&partnerID=8YFLogxK
U2 - 10.1016/j.jcrysgro.2021.126265
DO - 10.1016/j.jcrysgro.2021.126265
M3 - Article
AN - SCOPUS:85111798829
VL - 572
JO - Journal of Crystal Growth
JF - Journal of Crystal Growth
SN - 0022-0248
M1 - 126265
ER -
