Fabrication of Potentiometric Enzyme Sensors Based on a pH-Sensitive Polymer-Coated Ag Electrode

Jun Ichi Anzai, Masahiko Shimada, Hongda Fu, Tetsuo Osa

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A silver wire electrode coated with a poly (vinyl chloride)/tri-n-dodecylamine composite membrane was used to fabricate potentiometric enzyme sensors. The coated Ag electrode was further covered with a penicillinase or urease membrane to make a penicillin or urea sensor, respectively. The penicillin sensor was useful for determining penicillin at concentrations of millimolar level. Some operating variables such as pH and ionic concentration of the working buffer of the sensor were examined. The urea sensor could be used to determine urea in human blood.

Original languageEnglish
Pages (from-to)4568-4573
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume35
Issue number11
DOIs
Publication statusPublished - 1987 Jan 1

Keywords

  • coated wire electrode
  • enzyme electrode
  • pH-sensitive electrode
  • penicillin sensor
  • poly(vinyl chloride)/tri-n-dodecylamine composite membrane
  • urea sensor

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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