Fabrication of novel biodegradable particles and application for DDS by self-organized precipitation method

Daisuke Ohsato, Takeshi Higuchi, Hiroshi Yabu, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

Research output: Contribution to conferencePaper

Abstract

Recently, we have reported the formation of nano-particles by mixing a poor solvent into a solution of polymer, and then evaporating a good solvent. In this report, nano-particles were prepared from various biodegradable polymers. Average size of the particles was measured by dynamic light scattering spectrophotometer. The particles were observed by Field-Emission Scanning Electron Microscopy. Uniform sized particles were formed. The particle size was controlled ranging from 100 nm to 1000 nm. In the case of Poly(ε- caprolactone)(PCL), the particle size became larger with increasing the concentration of solution, and increasing the volume ratio of a good solvent / a poor solvent. Fabrication of biodegradable particles containing a drug and the concentration of drug in the particles will be reported.

Original languageEnglish
Pages4949-4950
Number of pages2
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

Keywords

  • Biodegradable particles
  • Drug
  • Drug Delivery System
  • Self-organization

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Fabrication of novel biodegradable particles and application for DDS by self-organized precipitation method'. Together they form a unique fingerprint.

  • Cite this

    Ohsato, D., Higuchi, T., Yabu, H., Tanaka, M., Yamamoto, S., & Shimomura, M. (2005). Fabrication of novel biodegradable particles and application for DDS by self-organized precipitation method. 4949-4950. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.