@inproceedings{731205fb558d4913b1cb32ccf2bc7a11,
title = "Fabrication of multiphenotype cell arrays within reversibly sealed microfluidic channels for high-throughput analysis",
abstract = "We present a soft lithographic method to fabricate multiphenotype cell arrays by capturing cells within an array of reversibly sealed microfluidic channels made of elastomeric polydimethylsiloxane (PDMS) molds. Upon formation of the cell arrays on the substrate, the PDMS mold could be removed, and the orthogonal alignment and subsequent attachment of a secondary array of channels on the patterned substrates could be used to sequentially deliver fluids to the patterned cells. The ability to position many cell types on particular regions within a two-dimensional substrate could potentially lead to improved high-throughput methods applicable to drug screening and tissue engineering.",
keywords = "Cellular arrays, Microfluidics, Multi-phenotype, PDMS",
author = "Ali Khademhosseini and George Eng and Judy Yeh and Jeffrey Karp and Hirokazu Kaji and Jeffrey Borenstein and Omid Farokhzad and Robert Langer",
year = "2005",
month = jan,
day = "1",
language = "English",
isbn = "0974361119",
series = "Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Transducer Research Foundation",
pages = "886--888",
booktitle = "Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference",
note = "9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 ; Conference date: 09-10-2005 Through 13-10-2005",
}