Fabrication of Multichannel Neural Microelectrodes with Microfluidic Channels Based on Wafer Bonding Technology

R. Kobayashi, S. Kanno, Takafumi Fukushima, Tetsu Tanaka, Mitsumasa Koyanagi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

We have proposed the intelligent Si neural probe which can realize high density and multifunctional recording of neuronal behaviors. In this device, LSI chips such as amplifiers, A/D converters, and multiplexers are integrated on the Si neural probe. In this paper, we report the development of a novel multichannel Si neural microelectrode with microfluidic channels which is the key part of the intelligent Si neural probe. The microelectrode has microfluidic channels fabricated using a wafer bonding technology to deliver drugs into the brain when neuronal action potentials are recorded. And also, our microelectrode has recording sites on both front- and backside of Si to realize high density recording. We fabricated the carefully-designed multichannel Si neural microelectrode, and we evaluated characteristics of both recording sites and microfluidic channels. From the liquid ejection test, we confirmed that there was no void at bonding faces. We observed the liner relationship between the flow rate and the pressure drop, and the relationship was identical to that from the calculation, which indicated that the microfluidic channel was successfully formed. Moreover, both front- and back-side recording sites had impedance values of 2.5 MΩ and 2.7 MΩ at 1 kHz, respectively, which indicated that both recording sites had equivalent characteristics. The neuronal action potentials from CA1 area in a hippocampal slice were successfully recorded by using the fabricated microelectrode.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
Pages2258-2261
Number of pages4
DOIs
Publication statusPublished - 2009 Dec 1
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 2008 Dec 32008 Dec 6

Publication series

NameIFMBE Proceedings
Volume23
ISSN (Print)1680-0737

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
Country/TerritorySingapore
Period08/12/308/12/6

Keywords

  • Si intelligent neural probe
  • multichannel neural microelectrode
  • simultaneous multi-site recording

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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