Fabrication of Hinokitiol-modified podophyllotoxin nano-prodrugs having a high drug loading capacity

Keita Tanita, Yoshitaka Koseki, Kazue Shimizu, Hirohito Umezawa, Hitoshi Kasai

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Nano-prodrug is a nanomedicine developed by the reprecipitation method, which allows nanoparticles to be fabricated by only prodrug molecules without using any nanocarriers. In the present study, we synthesized a heterodimer, composed of hinokitiol and podophyllotoxin (PPT) linked via different linkers of carbon chain length as new prodrug compounds, and fabricated their nano-prodrugs. We found that the longer the carbon chain linker, the smaller the size of nanoparticles, and the lower their cytotoxicity. We concluded that heterodimeric prodrugs can be fabricated into nano-prodrugs without reducing their drug loading capacity, and might eventually serve as a promising template for the development of novel nanomedicine.

    Original languageEnglish
    Pages (from-to)79-85
    Number of pages7
    JournalMolecular crystals and liquid crystals
    Volume706
    Issue number1
    DOIs
    Publication statusPublished - 2020 Jul 23

    Keywords

    • Heterodimeric prodrug
    • Hinokitiol
    • nano-prodrugs
    • podophyllotoxin (PPT)
    • reprecipitation method

    ASJC Scopus subject areas

    • Chemistry(all)
    • Materials Science(all)
    • Condensed Matter Physics

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