Fabrication of biodegradable particles for DDS by self-organized precipitation method

Daisuke Ohsato; Takeshi Higuchi; Hiroshi Yabu; Masaru Tanaka; Sadaaki Yamamoto; Masatsugu Shimomura

Fabrication of biodegradable particles for DDS by self-organized precipitation method

Daisuke Ohsato, Takeshi Higuchi, Hiroshi Yabu, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

Division of Measurements

Research output: Contribution to conference › Paper

Abstract

Recently, we have reported the formation of nano-particles by mixing a poor solvent into a solution of polymer, and then evaporating a good solvent. In this report, nano-particles were prepared from various biodegradable polymers. Average size of the particles was measured by dynamic light scattering spectrophotometer. The particles were observed by Field-Emission Scanning Electron Microscopy. Uniform sized particles were formed. The particle size was controlled ranging from 100 nm to 1000 nm. In the case of Poly(ε- caprolactone)(PCL), the particle size became larger with increasing the concentration of solution, and increasing the volume ratio of a good solvent / a poor solvent. Fabrication of biodegradable particles containing a drug and their concentration of drug in the particles will be reported.

Original language	English
Number of pages	1
Publication status	Published - 2005 Dec 1
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27

Other

Other	54th SPSJ Annual Meeting 2005
Country	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

Keywords

Biodegradable particles
Drug Delivery System
Self-organization

ASJC Scopus subject areas

Engineering(all)

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Ohsato, D., Higuchi, T., Yabu, H., Tanaka, M., Yamamoto, S., & Shimomura, M. (2005). Fabrication of biodegradable particles for DDS by self-organized precipitation method. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.

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AU - Ohsato, Daisuke

AU - Higuchi, Takeshi

AU - Yabu, Hiroshi

AU - Tanaka, Masaru

AU - Yamamoto, Sadaaki

AU - Shimomura, Masatsugu

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AB - Recently, we have reported the formation of nano-particles by mixing a poor solvent into a solution of polymer, and then evaporating a good solvent. In this report, nano-particles were prepared from various biodegradable polymers. Average size of the particles was measured by dynamic light scattering spectrophotometer. The particles were observed by Field-Emission Scanning Electron Microscopy. Uniform sized particles were formed. The particle size was controlled ranging from 100 nm to 1000 nm. In the case of Poly(ε- caprolactone)(PCL), the particle size became larger with increasing the concentration of solution, and increasing the volume ratio of a good solvent / a poor solvent. Fabrication of biodegradable particles containing a drug and their concentration of drug in the particles will be reported.

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KW - Drug Delivery System

KW - Self-organization

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