Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process

S. Takenaga, B. Schneider, E. Erbay, M. Biselli, Th Schnitzler, M. J. Schöning, T. Wagner

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.

Original languageEnglish
Pages (from-to)1347-1352
Number of pages6
JournalPhysica Status Solidi (A) Applications and Materials Science
Volume212
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1

Keywords

  • 3D printing
  • Chinese hamster ovary cell
  • fetal calf serum
  • lab-on-chip
  • light-addressable potentiometric sensor
  • microfluidics

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films

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