Fabrication and dual-modal imaging properties of quantum dot/silica core-shell particles with immobilized single-nanometer-sized gold nanoparticles

Mayu Tayama, Tomoya Inose, Noriko Yamauchi, Kouichi Nakashima, Masayuki Tokunaga, Chihiro Kato, Keiichiro Hatoyama, Takashi Kamei, Kohsuke Gonda, Yoshio Kobayashi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

This work develops a process for fabricating particles composed of a quantum dot (QD)core, a SiO2 shell, and single-nanometer-sized Au nanoparticles (AuS)immobilized on the particle surface. The QD nanoparticles were silica-coated with a sol-gel process using tetraethyl orthosilicate (QD/SiO2). A colloidal solution of the AuS was prepared by reducing Au3+ with tetrakis(hydroxymethyl)phosphonium chloride in an aqueous solution. The QD/SiO2 particles were surface-modified with thiol groups by using (3-mercaptopropyl)trimethoxysilane (QD/SiO2/SH). The AuS nanoparticles were immobilized on the QD/SiO2/SH particle surface by adding a colloidal AuS solution to a colloidal QD/SiO2/SH solution (QD/SiO2/SH/AuS). The QD/SiO2/SH/AuS particles were surface-modified with thiol-terminated polyethylene glycol (PEG)(QD/SiO2/SH/AuS/PEG). Fluorescence images and computed tomography (CT)images could be obtained for the colloidal QD/SiO2/SH/AuS/PEG particle solution. The colloidal QD/SiO2/SH/AuS/PEG particle solution had a CT value per unit concentration of Au (M)of 6.68 × 103 HU/M. The circulation of the QD/SiO2/SH/AuS/PEG particles was confirmed in a mouse after injection of a colloidal particle solution into its blood vessels, and they accumulated in the heart. A portion of the QD/SiO2/SH/AuS/PEG particles accumulated in the liver and spleen and remained there.

Original languageEnglish
Pages (from-to)162-170
Number of pages9
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume574
DOIs
Publication statusPublished - 2019 Aug 5

Keywords

  • Core-shell nanoparticle
  • Fluorescence imaging
  • Gold
  • Quantum dot
  • Silica-coating
  • X-ray imaging

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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