Fabrication and characterization of biodegradable nano-particles containing a drug for DDS by self-organized precipitation method

Daisuke Ohsato, Masaru Tanaka, Sadaaki Yamamoto, Takeshi Higuchi, Hiroshi Yabu, Masatsugu Shimomura

Research output: Contribution to conferencePaperpeer-review

Abstract

Recently, we have reported the preparation of nano-particles by mixing a poor solvent into a solution of polymer, and evaporating a good solvent. In this report, biodegradable polymer particles containing pyrene (Py) as a model compound of hydrophobic drug were fabricated. The morphology of particles was observed by FE-SEM. The content of Py in the particles was determined as c.a. 10 wt%. By measuring fluorescence spectra, we found that the Py in the particles was distributed in the state of monomer. Py was released about 80% over 200 hours in 10 mM sodium phosphate buffer (pH7.4).

Original languageEnglish
Number of pages1
Publication statusPublished - 2006 Oct 19
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

Keywords

  • DDS
  • Particles containing a drug
  • Self-organization

ASJC Scopus subject areas

  • Engineering(all)

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